High levels of passive safety were a priority at the design stage. As a result, the Infiniti G37 Coupé has a full complement of six airbags, with dual-stage front airbags, seat belt sensors and passenger seat occupancy sensor. The front seats incorporate hip and thorax bags, while there are front-to-rear curtain airbags for protection in a side impact.

Also standard is a pop-up bonnet, designed to offer greater crash protection for pedestrians. In the event of a collision, a small pyrotechnic charge raises the trailing edge of the bonnet close the lower edge of the windscreen. This creates a larger buffer between the bonnet and the top of the engine, providing a more yielding surface which in turn helps to reduce potential injuries.